Question About Complex Sampling Designs

Hello all. I am working with a large CDC survey combining multiple years of data and it is required that I use complex sampling procedures to analyze the data. Since this is a national survey and I’m analyzing multiple years combined, the sample size is quite large when raw and even larger when weighted (obviously!). I’m worried about being overpowered when I apply weights, however weighting it is required per CDC for more accurate interpretation of the findings and complex sampling procedures in SPSS require weighting to be input into the plan file. My question after all of this is 1) if anyone has general advice on what I described and 2) if weighting is always required when I am analyzing data that uses complex sampling designs? Thank you!!!